Dr. Perlmutter discusses new science regarding low-carb, high-fat diets (ketogenic), gut bacterial diversity and exercise for optimal brain health.

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————————————–Key Takeaways———————————-

02:07 Confusion Over Carbohydrates:
03:44 The Real Problem with Carbs:

05:29 Eating for Your Microbiome

07:44 Why Fat is Blamed

09:00 Gut Bacteria Diversity and FMT
FMT (Fecal Microbial Transplant) has been published in medical literature for 50 years or more. Delivering probiotics or fully formed microbiota via the rectal route offers huge potential. Today, more than 500 hospitals in America perform FMT for the treatment of C. diff. C. diff can be contracted via the use of acid blocking drugs or the use of antibiotics, both of which disrupt the complexity and diversity of your gut microbiome. The success rate of FMT for C. diff is 94 to 96%. The approved standard treatment with antibiotics is about 26 to 28% effective.

10:07 C-Sections: Maria Dominguez-Bello at NYU Medical School has published a series of papers. The most recent of which in the journal Nature, where she has advocated putting a swab in the vaginal birth canal prior to a C-section and mandatory intravenous antibiotics, keeping the swab in a warm moist environment. After the baby is born, inoculate baby’s face and mouth with the contents of the birth canal. These are the seeds for the microbiome.

13:30 Problems with High Fat in the Research:

16:18 Oral Microbiome: Studies of the oral microbiome of our ancestors found two dramatic times when there were changes: 10,000 years ago and 200 years ago. These correlate with the development of agriculture and the development of processed sugar. The reduction of diversity in our microbiome is passed down to the next generation.

21:46 Gut Bacteria and Heart Disease

26:53 Ketogenic Diet, Cancer and Brain Health

31:25 Ways to Boost BDNF

36:40 Stop and Connection

38:21 Dr. Perlmutter’s Morning Routine

40:48 Dr. Perlmutter’s Favorite Nutrient

41:33 Dr. Perlmutter’s Number #1 Health Tip


31 Replies to “David Perlmutter – Ketogenic Diet, Carbs & Gut Bacteria”

  1. Tremendous content…Loads of good info here about what bodybuilders call "Hippie Stuff". I'm currently researching combining both IF and Keto into one eating style. Just four days in so I'm still experiencing the initial water weight loss from lowering carbs(7lbs). I'll keep regular updates posted

  2. Awesome vid! I totally agree & have seen the results of this. And integrating magnesium oil into my life has been one of the pivotal/positive shifts in my overall well being. It totally helped my stress level go way down & feel more at peace. Sending peace, love & gratitude to you both.

  3. So, all the Asians who liven in rural parts of Asia who eat a mostly high-carb high-fiber diet, should be a bunch of fatties with metabolic syndrome??? No they don't. So forget the expensive paleo grass fed ketogenic diet, which is economically unsustainable, just eat like those rural vegan Asians! I wonder why doesn't this doctor advocate for such a high-fiber vegan diet???? I wonder if he gets money from the meat & dairy industry. But of course the doctor is also trying to sell his book in the US, and Americans are probably more receptive of a fatty ketogenic diet than a HEALTHIER (and more economically sustainable) vegan diet huh?

  4. Ketogenic diet is another extreme as vegan diet. We don't know how many carbs your ancestor ate, are they was in ketosis and etc. Ketosis is human response to starvation.
    Also all people are different, no one diet hit all. Ketogenic diet is another topic used for writing and selling books. Be critical about that other say and make your own decision after you research topic!

  5. Thank you so very much for your response! I needed this refresher on chemistry, and A&P:) I have been taking Magnesium at bedtime for a while and have been taking Himalayian sea salt in water with lemon every day and the symptoms have greatly subsided. I am still having some tachycardia during the night, but Nothing compared to what was happening when I began this new way of eating. I changed over to drinking water that contains electrolytes but I'm wondering if I should supplement with a postasium supplement? I also bought some keto test strips but am negative so I am guessing that it is going to take some time before I am adapted? Thank you again, so much; you really helped me tremendously.

  6. I'm normally not very impressed by doctors, but David is one of my heroes. I'm giving away copies of his latest book (The Whole Life Plan) as Christmas gifts to friends and family. Since many of those who are commenting are into fasting, here's how I do it: no breakfast (especially the breakfast of champions!) and no dinners, six days a week. In other words, I have copious lunches all week (little carbs, no sugars, no gluten, and plenty of healthy fat) and only water on Mondays. Works for me!

  7. We are all different and need different things. There are so many suggestions to how to eat, reasons why a person has skin problems,join problems and so on. Leaky gut is a new thing for me.Never heard about it before, but I have now. I have a skin problem, soon as I stop eating almost for a few weeks, (I was ill) my skin problem went away.So that was an eye opner for me. I have been trying all kinds of things for 13-15 years. Not eating this and that for years.Nothing help. But creams from the doc help while I used it.But after 4 days without cream, the skin essue came back. In general , I think the best is to eat lots of greens, protein,fibers, water, fruit,nuts, coconut. This ide of avoiding fruit just be course it has sugar in it is the wrong approach, atleast in my universe it is.Even fruit and berries has nurishment we need. Lots of people on youtube think that they are experts be course they have done some research. So mind what you follow.Do not walk with your head under the arm. ; – ). Balance is the key.

  8. Evolutionary considerations definitely make sense.   So, assuming we need to eat very close to pre-agricultural peoples wouldn't it make sense to find out what paleoanthropologists have to say?   So far as I can tell, the research suggests that it was comprised of a high fiber (around a 100 grams/d).   Dental studies seem to reinforce this.   This is not to say that fat from animals was not part of the diet, but hard to see how we evolved to eat a constant high fat diet.

  9. Newsflash about the way science works: if you say something ten years before everyone else, it's not because you are smart. It's because you are failing to wait until the data comes in on one side or the other. Saying something before it's the scientific consensus will get you on talk shows but it is essentially taking credit for others' hard work.

  10. started keto diet this week. started taking wheatgrass yesterday. Having Rapid heartbeats. Woke up at 3am with Rapid heartbeats. Having them now, sitting up, or when lying down???? Help????

  11. I wonder if paleo man really was in a keto state? No there wasn't grain but there was fruit which is carbs and sugar. Gorillas, chimps, orangutans, bonobos eat mostly fruit and leaves, and only rarely meat or animal fat. They get some fat from insects but I doubt they're in a keto state. African Bushman only get about 20-30% of calories from eating animals. Massai warriors and eskimos have more of a keto diet but have very low life expectancies. The highest life expectancies in the world are among people who eat plany based diets that include legumes (look up "blue zones" on national geographic). Why?

  12. As a layman much of this goes over my head ( the big words LoL) as a human being I've been saying how our diets over the 60's 70' 80's 90's etc has changed our gut health and health in gen. I grew up through much of those years eating those foods and am paying the price. The inflammation and lack of energy I have cannot continue. Ive been trying many things but am rather over whelmed and frustrated. No meat mostly organic veg and fruit need to cut some more carbs out. Going for consult re fecal transplant early next year.
    It is scary stuff thats happening to our food!!! Thanks for the post guys! :)

  13. here is a nice health Article for you ;

    ——-Handling Poultry Tied to Liver/Pancreatic Cancers——–
    We study those who have the most exposure. That’s how we learned about the potential cancer-causing dangers of asbestos, and that’s how we’re learning about the potential cancer-causing dangers of poultry viruses. For years I’ve talked about the excess mortality in poultry workers associated with these wart-causing chicken cancer viruses that may be transmitted to those in the general population handling fresh or frozen chicken (See Wart Cancer Viruses in Food).

    Last year I talked about the largest study at the time “confirming the findings of three other studies to date that workers in poultry slaughtering and processing plants have increased risk of dying from certain cancers,” that also added penis cancer to the risks linked to poultry exposure (See Poultry and Penis Cancer). That was looking at 20,000 poultry workers. Well, we have yet another study, now looking at 30,000.

    The purpose of the study, profiled in my video, Poultry Tied to Liver and Pancreatic Cancer, was to test the hypothesis that exposure to poultry cancer-causing viruses that widely occurs occupationally in poultry workers—not to mention the general population—may be associated with increased risks of deaths from liver and pancreatic cancers. They found that those who slaughter chickens have about nine times the odds of both pancreatic cancer and liver cancer.

    Just to put this in context, the most carefully studied risk factor for pancreatic cancer, one of our deadliest cancers, is cigarette smoking. Even if we smoke for more than 50 years, though, we “only” about double our odds of pancreatic cancer. Those who slaughter poultry appear to have nearly nine times the odds of geting pancreatic cancer .

    For liver cancer the most well-known and studied cause is alcohol. Those who consume more than four drinks a day have triple the odds of liver cancer.
    As with pancreatic cancer, poultry slaughtering appears to increase one’s odds of getting liver cancer nine-fold. Thus, the cancer-causing viruses in poultry may explain the increasing risk of death from liver and pancreatic cancers.

    There are diseases unique to the meat industry like the newly described “salami brusher’s disease” that affects those whose job it is to wire brush off the white mold that naturally grows on salami for eight hours a day, but most diseases suffered by meat workers are more universal. The reason the connection between asbestos and cancer was so easy to nail down is that asbestos caused a particularly unusual cancer, which was virtually unknown until there was widespread asbestos mining and industrial use.

    The pancreatic cancer one might get from handling chicken, however, is the same pancreatic cancer one might get smoking cigarettes, so it’s more difficult to tease out a cause-and-effect-relationship. Bottom line: despite the extremely high risks of deadly cancers, don’t expect an asbestos-type ban on Kentucky Fried Chicken anytime soon.


    Joevegan • 3 months ago ;

    I've worked in a soup kitchen for about 3 years. A couple of years ago I noticed a small wart on the palm of my hand. I had just come across this website and began devouring the information here. I now wear gloves when handling raw meats. The wart has gone away, I believe, thanks to my WFPB diet. I frequently print articles from this website to share; since I'm the only vegan I know I get asked a lot of questions. I am having an influence, I'm allowed to prepare a small amount of a vegetarian (often vegan) option.
    I'm printing this article to share with the other cooks, who don't wear gloves when handling raw meats. Thank you for the information; I wonder how many cancers you will prevent and lives you save because of the information you distribute .
    Show less

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