All Essential Benefits/Effects/Facts & Information
7-oxodehydroepiandrosterone (7-oxo DHEA and more commonly known as the brand name 7-keto) is one of three oxygenated metabolites of dehydroepiandrosterone, and these three oxygenated metabolites interconvert with one another but do not convert back into parent DHEA; 7-keto supplementation is a way to get these three oxygenated metabolites without using DHEA supplementation, and DHEA may form androgenic and estrogenic hormones via an alternate metabolic pathway (which 7-keto does not participate in).

7-keto supplementation is mostly known to not be hormonal; it can interact with steroid metabolism but the exact manner in which it does it not fully elucidated. It does appear to have anti-cortisol mechanisms as the enzymes that activate cortisol (from the relatively inactive precursors of cortisone and corticosterone) are the same that interconvert these oxygenated metabolites. Although it appears to be anti-cortisol by its mechanisms, there is insufficient evidence to support these mechanisms in the body following oral supplementation.

Studies using 7-keto supplementation tend to note an increased metabolic rate later on during a caloric restriction period (which is secondary to reducing the rate of metabolic rate decline associated with dieting, and becoming a relative increase) although the quantity of data on this is pretty minimal if we exclude studies with possible conflicts of interest or those that use 7-keto alongside a multitude of supplements.

7-keto appears to be a somewhat promising non-hormonal fat burning agent but requires more evidence on both of those claims.

Audio podcast version:


Dr. Dominic D’agostino is a tenured professor at the University of South Florida involved in cutting edge research on the ketogenic diet’s applications in areas such as cancer therapies, Alzheimer’s treatment, and more. We got into some fascinating topics such as performance enhancement applications of a ketogenic diet in the context of military special forces, how manta rays utilize ketosis, potential benefits of exogenous ketones in emergency medical situations, the vital importance of DHA, why fish should be a ketogenic staple food, and much more. This is a gem of an episode. Enjoy.

Dom’s fiancé, Csilla Ari recently did a TED talk on her research into the brains of manta rays and why they need to be protected and studied:


Dominic’s site:


29 Replies to “New Ketogenic Research, DHA and Keto”

  1. Hi PrimalEdge…have you seen the food documentary called food choices? They promote the plant based diet. They say ketogenic diet is harmful. It seems to be all the same Doctors that make all the other food documentaries. Curious if you've seen it and your thoughts on 90% plant base diets.

  2. Big fan of your longer pieces Tristan. This interview was right up there with the 2 you did with Jack Kruse and unlike (all of Jack's interviews), I didn't get a headache trying to keep up.

  3. Today started my 6 week on Ketosis. Been sleeping well, not hungry, gym workouts good. good on salt, potassium, magnesium, doing 70/25/5 but all sudden sudden sooooo sleepy and some cravings after lunch time. Where can I find more info. on this

  4. Awesome I interview. Inspired me to cut back on the beef and chicken and add more fish into my diet. Moving back to Florida in a few months where fresh seafood will be more available and affordable.

  5. Supposedly insulin resistance in the rest of the body can be a rapid response to blood loss to spare glucose for the brain.

    It'd be interesting to see how administering ketone esters could play in to that.

  6. I would love to hear you two talk about the best types of canned fish and ways for fish haters to eat it. I can hardly choke down fish, but I'm working on liking it. Time to put my big-girl panties on! My husband has had me try boneless/skinless canned fish, which I like but doesn't have enough fat. Also, I did not realize oysters are another good source of omega 3s.

  7. Really like the interviews, but was wondering if you can break up the longer ones into shorter clips? I tend to watch them while traveling so sometimes the airport/public wifi tends to be a bit slow making anything longer than 10 minutes difficult to watch.

  8. Man, D'agostino is just at the frontier of human metabolic performance. His work will change the notion of ketosis aswell as nutrition in general. I just love how he has so many ideas of possible studies to conduct. Too bad those are still experimental and require the public to still overcome their fear of fat. It will happen soon though, then people like Dom will accelerate the use of ketosis in all areas. Solid episode once again Tristan, keeping regular updates with D'agostino's work is a great thing to do to keep us informed with what's going on in science.

  9. For my case specifically, low DHA levels are happening because of lots of nnEMF in my environment, especially in the winter when I don't have much sunlight. I also eat a crap-ton of seafood in the winter. It's helped a little, but I'm slammed with nnEMF because of my work and others around me.

  10. I am a type 1 diabetic. A very low carb ketogenic diet is the only way that I have found to control my type 1 diabetes, i works miracles. Check out Dr. Richard Bernstein and Dr, Keith Runyan for more information (both are type 1s). About what was mentioned in the video about type 1 diabetics, as long as you have the right basal amount of insulin in your body, you will not go into diabetic ketoacidosis. Check out

  11. wow this was fascinating and learned so much. thank you for the great work. on the fun side, are you in some sort of competition for having the biggest jar to drink water? in every video it gets bigger :)

  12. What wonderfuly informative interview.. I really hope to read some of his findings once they become available.. I always learn so much more with each interview you do, so thank you~

  13. Very cool! I think you guys may have danced around the subject of the quality of DHA in canned fish. Do you know anymore about whether or not canned fish is a good source of DHA and also how does it compare with a dose of high quality fish oil? Thanks again!

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